Biochemistry of mitochondrial coenzyme Q biosynthesis

JA Stefely, DJ Pagliarini - Trends in biochemical sciences, 2017 - cell.com
Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid produced across all domains of life
that functions in electron transport and oxidative phosphorylation and whose deficiency …

Coenzyme Q10 deficiencies: pathways in yeast and humans

AM Awad, MC Bradley… - Essays in …, 2018 - portlandpress.com
Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial
respiratory electron transport and serves as an important antioxidant. In human and yeast …

Plastoquinone and ubiquinone in plants: biosynthesis, physiological function and metabolic engineering

M Liu, S Lu - Frontiers in Plant Science, 2016 - frontiersin.org
Plastoquinone (PQ) and ubiquinone (UQ) are two important prenylquinones, functioning as
electron transporters in the electron transport chain of oxygenic photosynthesis and the …

[HTML][HTML] Diversity of the reaction mechanisms of SAM-dependent enzymes

Q Sun, M Huang, Y Wei - Acta Pharmaceutica Sinica B, 2021 - Elsevier
S-adenosylmethionine (SAM) is ubiquitous in living organisms and is of great significance in
metabolism as a cofactor of various enzymes. Methyltransferases (MTases), a major group …

Biosynthesis of coenzyme Q in eukaryotes

M Kawamukai - Bioscience, biotechnology, and biochemistry, 2016 - academic.oup.com
Coenzyme Q (CoQ) is a component of the electron transport chain that participates in
aerobic cellular respiration to produce ATP. In addition, CoQ acts as an electron acceptor in …

The Paradox of Coenzyme Q10 in Aging

ME Díaz-Casado, JL Quiles, E Barriocanal-Casado… - Nutrients, 2019 - mdpi.com
Coenzyme Q (CoQ) is an essential endogenously synthesized molecule that links different
metabolic pathways to mitochondrial energy production thanks to its location in the …

An S-methyltransferase that produces the climate-active gas dimethylsulfide is widespread across diverse marine bacteria

Y Zhang, C Sun, Z Guo, L Liu, X Zhang, K Sun… - Nature …, 2024 - nature.com
Abstract Hydrogen sulfide (H2S), methanethiol (MeSH) and dimethylsulfide (DMS) are
abundant sulfur gases with roles in biogeochemical cycling, chemotaxis and/or climate …

Biocatalytic Friedel‐Crafts Reactions

RB Leveson‐Gower, G Roelfes - ChemCatChem, 2022 - Wiley Online Library
Friedel‐Crafts alkylation and acylation reactions are important methodologies in synthetic
and industrial chemistry for the construction of aryl‐alkyl and aryl‐acyl linkages that are …

A Universal, Continuous Assay for SAM‐dependent Methyltransferases

MJ Menke, P Schneider… - Angewandte Chemie …, 2023 - Wiley Online Library
Enzyme‐catalyzed late‐stage functionalization (LSF), such as methylation of drug molecules
and lead structures, enables direct access to more potent active pharmaceutical ingredients …

[HTML][HTML] Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis

TPT Nguyen, A Casarin, MA Desbats, M Doimo… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Coq5 catalyzes the only C-methylation involved in the biosynthesis of coenzyme Q (Q or
ubiquinone) in humans and yeast Saccharomyces cerevisiae. As one of eleven …