The past decade has seen tremendous developments in novel cancer therapies through the
targeting of tumor-cell-intrinsic pathways whose activity is linked to genetic alterations and …

Mammalian defensins are small, cationic, antimicrobial peptides encoded by the host that
are considered to be important antibiotic-like effectors of innate immunity. By using …

β-Defensins are small antimicrobial peptides of the innate immune system produced in
response to microbial infection of mucosal tissue and skin. We demonstrate that murine β …

Mammals generate a diverse array of antimicrobial proteins, largely represented by
defensins or cathelicidins. The direct in vitro microbicidal activity of antimicrobial proteins …

DNA vaccines were introduced less than a decade ago but have already been applied to a
wide range of infectious and malignant diseases. Here we review the current understanding …

Inducing effective anti-tumor immunity has become a major therapeutic strategy against
cancer. Dendritic cells (DC) are a heterogenous population of antigen presenting cells that …

Ion channels on the mitochondrial inner membrane influence cell function in specific ways
that can be detrimental or beneficial to cell survival. At least one type of potassium (K+) …

Chemokines, a superfamilly of small cytokine-like molecules, regulate leukocyte transport in
the body. In recent years, we have witnessed the transition of immunotherapeutic strategies …

Lymphoplasmacytic lymphoma (LPL) is an incurable low-grade lymphoma with no standard
therapy. Nine asymptomatic patients treated with a first-in-human, neoantigen DNA vaccine …

Chemokine receptors are differentially expressed on immature and mature dendritic cells
(DC). Herein, we demonstrate for the first time that murine antimicrobial peptides β …