Extracellular vesicles versus synthetic nanoparticles for drug delivery

KW Witwer, J Wolfram - Nature Reviews Materials, 2021 - nature.com
Cell-released biological nanoparticles, that is, extracellular vesicles (EVs), are emerging
drug carriers with high complexity. EV-based drug delivery exploits intrinsic mechanisms for …

[HTML][HTML] New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)

CP Palanisamy, JJ Pei, P Alugoju, NVA Anthikapalli… - Theranostics, 2023 - ncbi.nlm.nih.gov
Neurodegenerative diseases are characterized by the progressive loss of neurons and
intricate interactions between different cell types within the affected regions. Reliable …

Mesenchymal stem cell-derived extracellular vesicles: opportunities and challenges for clinical translation

M Maumus, P Rozier, J Boulestreau… - … in Bioengineering and …, 2020 - frontiersin.org
Extracellular vesicles (EVs), including exosomes and microvesicles, derived from
mesenchymal stem/stromal cells (MSCs) exert similar effects as their parental cells, and are …

[HTML][HTML] Targeted delivery of extracellular vesicles in heart injury

P Chen, L Wang, X Fan, X Ning, B Yu, C Ou… - Theranostics, 2021 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are nanoscale extracellular vesicles derived from endocytosis
that are crucial to intercellular communication. EVs possess natural biocompatibility and …

Mesenchymal stem cell-derived extracellular vesicles for therapeutic use and in bioengineering applications

C McLaughlin, P Datta, YP Singh, A Lo, S Horchler… - Cells, 2022 - mdpi.com
Extracellular vesicles (EVs) are small lipid bilayer-delimited particles that are naturally
released from cells into body fluids, and therefore can travel and convey regulatory functions …

Intrathecal administration of conditioned serum from different species resolves Chemotherapy-Induced neuropathic pain in mice via secretory exosomes

T Buchheit, Y Huh, A Breglio, S Bang, J Xu… - Brain, behavior, and …, 2023 - Elsevier
Chemotherapy-induced peripheral neuropathy (CIPN) is the most prevalent neurological
complication of chemotherapy for cancer, and has limited effective treatment options …

Mesenchymal stem cell-derived exosomes: a promising therapeutic agent for the treatment of liver diseases

Y Ding, Q Luo, H Que, N Wang, P Gong… - International journal of …, 2022 - mdpi.com
Liver disease has become a major global health and economic burden due to its broad
spectrum of diseases, multiple causes and difficult treatment. Most liver diseases progress to …

Practical considerations for translating mesenchymal stromal cell-derived extracellular vesicles from bench to bed

PPY Lui, YT Leung - Pharmaceutics, 2022 - mdpi.com
Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) have shown
potential for the treatment of tendon and ligament injuries. This approach can eliminate the …

Secretomes as an emerging class of bioactive ingredients for enhanced cosmeceutical applications

KX Tan, T Chang, X Lin - Experimental Dermatology, 2022 - Wiley Online Library
Skin ageing is predominantly caused by either intrinsic or extrinsic factors, leading to
undesirable skin features. Advancements in both molecular and cellular fields have created …

Challenges and future scope of exosomes in the treatment of cardiovascular diseases

P Ranjan, K Colin, RK Dutta… - The Journal of …, 2023 - Wiley Online Library
Exosomes are nanosized vesicles that carry biologically diverse molecules for intercellular
communication. Researchers have been trying to engineer exosomes for therapeutic …