A Colorimetric Assay to Identify and Characterize Bacterial Primase Inhibitors

AH Pang, OV Tsodikov - Antibiotics: Methods and Protocols, 2022 - Springer
Bacterial DNA primase DnaG is an attractive target for antibiotic discovery since it plays an
essential role in DNA replication. Over the last 10 years, we have developed and optimized …

Inhibition of Replication Fork Formation and Progression: Targeting the Replication Initiation and Primosomal Proteins

HM Radford, CJ Toft, AE Sorenson… - International Journal of …, 2023 - mdpi.com
Over 1.2 million deaths are attributed to multi-drug-resistant (MDR) bacteria each year.
Persistence of MDR bacteria is primarily due to the molecular mechanisms that permit fast …