The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

The skin offers an ideally suited, clinically relevant model for studying the crossroads
between peripheral and systemic responses to stress. A 'brain–skin connection'with local …

During neuronal‐induced inflammation, mast cells may respond to stimuli such as
neuropeptides in an FcεRI‐independent manner. In this study, we characterized human …

The peptide substance P (SP) has been implicated in inflammatory conditions, such as
psoriasis, where mast cells and VEGF are increased. A relationship between SP and VEGF …

Mast cell stabilizing drugs inhibit the release of allergic mediators from mast cells and are
used clinically to prevent allergic reactions to common allergens. Despite the relative …

Mast cells play a critical role in type 1 hypersensitivity reactions. Indeed, mast cell mediators
are implicated in many different conditions including allergic rhinitis, conjunctivitis, asthma …

Mast cells (MCs) are bone-marrow-derived haematopoietic cells that are widely distributed
in human tissues. When activated, they will release tryptase, histamine and other mediators …

Substance P and its receptor (R) neurokinin (NK)-1 may have a role in the pathogenesis of
psoriasis. Stress has been reported to play a role in the onset and exacerbation of psoriasis …

For decades, research has demonstrated that chronic diseases characterized by
dysregulation of inflammation are particularly susceptible to exacerbation by stress and …

Background Various mediators of pruritus have been suggested that might be responsible
for the mechanism of pruritus in psoriasis. Objectives To study the expression levels of …