The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …

Studies over the past 20 years have defined the Hippo signaling pathway as a major
regulator of tissue growth and organ size. Diverse roles for the Hippo pathway have …

The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and
Lats) and downstream transcription coactivators (YAP and TAZ), plays a key role in tissue …

Vertebrates have a unique 3D body shape in which correct tissue and organ shape and
alignment are essential for function. For example, vision requires the lens to be centred in …

Stem cell (SC) activity fluctuates throughout an organism's lifetime to maintain homeostatic
conditions in all tissues. As animals develop and age, their organs must remodel and …

Force production and the propagation of stress and strain within embryos and organisms are
crucial physical processes that direct morphogenesis. In addition, there is mounting …

The balance between stem cell potency and lineage specification entails the integration of
both extrinsic and intrinsic cues, which ultimately influence gene expression through the …

Simple Summary YAP/TAZ are the central effectors of the Hippo pathway and orchestrate
their oncogenic program by binding to TEAD transcriptional factors. Here, we document a …

Embryonic induction is a key mechanism in development that corresponds to an interaction
between a signalling and a responding tissue, causing a change in the direction of …

The periodic segmentation of the vertebrate body axis into somites, and later vertebrae,
relies on a genetic oscillator (the segmentation clock) driving the rhythmic activity of …