Fundamental limits to cellular sensing

PR ten Wolde, NB Becker, TE Ouldridge… - Journal of Statistical …, 2016 - Springer
In recent years experiments have demonstrated that living cells can measure low chemical
concentrations with high precision, and much progress has been made in understanding …

Thermodynamic uncertainty relation for biomolecular processes

AC Barato, U Seifert - Physical review letters, 2015 - APS
Biomolecular systems like molecular motors or pumps, transcription and translation
machinery, and other enzymatic reactions, can be described as Markov processes on a …

Information processing in bacteria: memory, computation, and statistical physics: a key issues review

G Lan, Y Tu - Reports on Progress in Physics, 2016 - iopscience.iop.org
Living systems have to constantly sense their external environment and adjust their internal
state in order to survive and reproduce. Biological systems, from as complex as the brain to …

Estimating entropy production from waiting time distributions

DJ Skinner, J Dunkel - Physical review letters, 2021 - APS
Living systems operate far from thermal equilibrium by converting the chemical potential of
ATP into mechanical work to achieve growth, replication, or locomotion. Given time series …

Improved bounds on entropy production in living systems

DJ Skinner, J Dunkel - … of the National Academy of Sciences, 2021 - National Acad Sciences
Living systems maintain or increase local order by working against the second law of
thermodynamics. Thermodynamic consistency is restored as they consume free energy …

The free-energy cost of accurate biochemical oscillations

Y Cao, H Wang, Q Ouyang, Y Tu - Nature physics, 2015 - nature.com
Oscillations within the cell regulate the timing of many important life cycles. However, in this
noisy environment, oscillations can be highly inaccurate owing to phase fluctuations. It …

Efficiency of cellular information processing

AC Barato, D Hartich, U Seifert - New Journal of Physics, 2014 - iopscience.iop.org
We show that a rate of conditional Shannon entropy reduction, characterizing the learning of
an internal process about an external process, is bounded by the thermodynamic entropy …

Universal minimal cost of coherent biochemical oscillations

L Oberreiter, U Seifert, AC Barato - Physical Review E, 2022 - APS
Biochemical clocks are essential for virtually all living systems. A biochemical clock that is
isolated from an external periodic signal and subjected to fluctuations can oscillate …

Optimal resource allocation in cellular sensing systems

CC Govern, PR Ten Wolde - Proceedings of the National …, 2014 - National Acad Sciences
Living cells deploy many resources to sense their environments, including receptors,
downstream signaling molecules, time, and fuel. However, it is not known which resources …

Olfactory receptor neurons use gain control and complementary kinetics to encode intermittent odorant stimuli

S Gorur-Shandilya, M Demir, J Long, DA Clark… - Elife, 2017 - elifesciences.org
Insects find food and mates by navigating odorant plumes that can be highly intermittent,
with intensities and durations that vary rapidly over orders of magnitude. Much is known …