Muscarinic receptor signaling in the pathophysiology of asthma and COPD
Anticholinergics are widely used for the treatment of COPD, and to a lesser extent for
asthma. Primarily used as bronchodilators, they reverse the action of vagally derived …
asthma. Primarily used as bronchodilators, they reverse the action of vagally derived …
Signaling and regulation of G protein-coupled receptors in airway smooth muscle
CK Billington, RB Penn - Respiratory research, 2003 - Springer
Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth
muscle (ASM) functions including contraction, growth, and" synthetic" functions that …
muscle (ASM) functions including contraction, growth, and" synthetic" functions that …
Effects of ginger and its constituents on airway smooth muscle relaxation and calcium regulation
EA Townsend, ME Siviski, Y Zhang, C Xu… - American journal of …, 2013 - atsjournals.org
The prevalence of asthma has increased in recent years, and is characterized by airway
hyperresponsiveness and inflammation. Many patients report using alternative therapies to …
hyperresponsiveness and inflammation. Many patients report using alternative therapies to …
CD38‐cyclic ADP‐ribose‐mediated Ca2+ signaling contributes to airway smooth muscle hyperresponsiveness
DA Deshpande, TF Walseth, RA Panettieri… - The FASEB …, 2003 - Wiley Online Library
We previously demonstrated that cyclic ADP‐ribose (cADPR) elicits Ca2+ release in airway
smooth muscle (ASM) cells through ryanodine receptor channels. CD38 is a cell surface …
smooth muscle (ASM) cells through ryanodine receptor channels. CD38 is a cell surface …
[HTML][HTML] Molecular mechanisms underlying airway smooth muscle contraction and proliferation: implications for asthma
G Pelaia, T Renda, L Gallelli, A Vatrella, MT Busceti… - Respiratory …, 2008 - Elsevier
Airway smooth muscle (ASM) plays a key role in bronchomotor tone, as well as in structural
remodeling of the bronchial wall. Therefore, ASM contraction and proliferation significantly …
remodeling of the bronchial wall. Therefore, ASM contraction and proliferation significantly …
Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening
Alzheimer's disease (AD) therapeutics based on the amyloid hypothesis have shown
minimal efficacy in patients, suggesting that the activity of amyloid beta (Aβ) represents only …
minimal efficacy in patients, suggesting that the activity of amyloid beta (Aβ) represents only …
Targeting G protein-coupled receptor signaling in asthma
DA Deshpande, RB Penn - Cellular signalling, 2006 - Elsevier
The complex disease asthma, an obstructive lung disease in which excessive airway
smooth muscle (ASM) contraction as well as increased ASM mass reduces airway lumen …
smooth muscle (ASM) contraction as well as increased ASM mass reduces airway lumen …
Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?
The cellular and molecular mechanisms that are involved in airway hyper-responsiveness
are unclear. Current studies suggest that tumor necrosis factor (TNF)-α, a cytokine that is …
are unclear. Current studies suggest that tumor necrosis factor (TNF)-α, a cytokine that is …
Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4
EA Townsend, CW Emala Sr - American Journal of …, 2013 - journals.physiology.org
Asthma is a disease of the airways with symptoms including exaggerated airway narrowing
and airway inflammation. Early asthma therapies used methylxanthines to relieve symptoms …
and airway inflammation. Early asthma therapies used methylxanthines to relieve symptoms …
CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle
The contractility of airway smooth muscle cells is dependent on dynamic changes in the
concentration of intracellular calcium. Signaling molecules such as inositol 1, 4, 5 …
concentration of intracellular calcium. Signaling molecules such as inositol 1, 4, 5 …