Toxicology and pharmacology of synthetic organoselenium compounds: An update

CW Nogueira, NV Barbosa, JBT Rocha - Archives of Toxicology, 2021 - Springer
Here, we addressed the pharmacology and toxicology of synthetic organoselenium
compounds and some naturally occurring organoselenium amino acids. The use of …

Organoselenium compounds as mimics of selenoproteins and thiol modifier agents

NV Barbosa, CW Nogueira, PA Nogara… - Metallomics, 2017 - academic.oup.com
Selenium is an essential trace element for animals and its role in the chemistry of life relies
on a unique functional group: the selenol (–SeH) group. The selenol group participates in …

A comprehensive review on the neuropathophysiology of selenium

M Naderi, P Puar, M Zonouzi-Marand… - Science of the Total …, 2021 - Elsevier
As an essential micronutrient, selenium (Se) exerts its biological function as a catalytic entity
in a variety of enzymes. From a toxicological perspective, however, Se can become …

Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase

G Liu, D Sil, N Maio, WH Tong, JM Bollinger Jr… - Nature …, 2020 - nature.com
Heme biosynthesis and iron-sulfur cluster (ISC) biogenesis are two major mammalian
metabolic pathways that require iron. It has long been known that these two pathways …

Quercetin protects the impairment of memory and anxiogenic-like behavior in rats exposed to cadmium: Possible involvement of the acetylcholinesterase and Na+, K+ …

FH Abdalla, R Schmatz, AM Cardoso, FB Carvalho… - Physiology & …, 2014 - Elsevier
The present study investigated the effects of quercetin in the impairment of memory and
anxiogenic-like behavior induced by cadmium (Cd) exposure. We also investigated possible …

In silico Studies on the Interaction between Mpro and PLpro From SARS‐CoV‐2 and Ebselen, its Metabolites and Derivatives

PA Nogara, FB Omage, GR Bolzan… - Molecular …, 2021 - Wiley Online Library
The COVID‐19 pandemic caused by the SARS‐CoV‐2 has mobilized scientific attention in
search of a treatment. The cysteine‐proteases, main protease (Mpro) and papain‐like …

Involvement of oxidative stress in 4-vinylcyclohexene-induced toxicity in Drosophila melanogaster

AO Abolaji, JP Kamdem, TH Lugokenski… - Free Radical Biology …, 2014 - Elsevier
Vinylcyclohexene (VCH) is a dimer of 1, 3-butadiene produced as a by-product of pesticides,
plastic, rubber, flame retardants, and tire production. Although, several studies have …

Dexmedetomidine decreases the inflammatory response to myocardial surgery under mini-cardiopulmonary bypass

NMH Bulow, E Colpo, RP Pereira… - Brazilian Journal of …, 2016 - SciELO Brasil
Cardiopulmonary bypass (CPB) with extracorporeal circulation produces changes in the
immune system accompanied by an increase in proinflammatory cytokines and a decrease …

[HTML][HTML] Synthesis and antioxidant properties of novel quinoline–chalcogenium compounds

L Savegnago, AI Vieira, N Seus, BS Goldani… - Tetrahedron …, 2013 - Elsevier
Herein we describe our results on the synthesis and antioxidant properties of 4-
arylchalcogenyl-7-chloroquinolines. This new class of compounds has been synthesized in …

Association of oxidative stress to the genesis of anxiety: implications for possible therapeutic interventions

W Hassan, C Eduardo Barroso Silva… - Current …, 2014 - ingentaconnect.com
Oxidative stress caused by reactive species, including reactive oxygen species, reactive
nitrogen species, and unbound, adventitious metal ions (eg, iron [Fe] and copper [Cu]), is an …