Lupeol is a natural triterpenoid that widely exists in edible fruits and vegetables, and
medicinal plants. In the last decade, a plethora of studies on the pharmacological activities …

Hypoxia, a condition of low oxygen availability, is a hallmark of tumour microenvironment
and promotes cancer progression and resistance to therapy. Many studies reported the …

Tumor cell vasculogenic mimicry (VM), also dubbed vascular mimicry, describes the
plasticity of aggressive cancer cells forming de novo vascular networks and is associated …

Kaempferol is a well‐known natural flavonol reported to be a potential treatment for multiple
cancers. In this study, we demonstrated that cell growth of androgen‐sensitive LNCaP cells …

Background Plant triterpenoids are major sources of nutraceuticals that provide many health
benefits to humans. Lupeol is one of the pentacyclic dietary triterpenoids commonly found in …

Background Phytosterols are naturally occurring steroid alcohols with excellent nutritional
values and wellness effects on lowering both the blood cholesterol and the ratio of the low …

Malignant melanoma is a tumor characterized by a very high level of heterogeneity,
responsible for its malignant behavior and ability to escape from standard therapies. In this …

Vasculogenic mimicry (VM), defined as an endothelial cell independent alternative
mechanism of blood and nutrient supply by dysregulated tumor cells, is associated with poor …

Cancer stem cells (CSCs) are involved in the metastatic process, the resistance of many
types of cancer to therapeutic treatments and consequently the onset of recurrences. The …

Background: The resistance of cancer cells to different therapies is one of the major
stumbling blocks for successful cancer treatment. Various natural and pharmaceuticals …