1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Protein ubiquitination regulates almost every process in eukaryotic cells. The study of the
many enzymes involved in the ubiquitination system and the development of ubiquitination …

Ubiquitin is a 76-amino acid regulatory protein involved in many important cellular
processes. Ubiquitin can be attached to other proteins at either a lysine residue or to the N …

Advancement in our knowledge of deubiquitinases (DUBs) and their biological functions
requires biochemical tools permitting interrogation of DUB activities under physiologically …

Ubiquitin (UB) transfer cascades consisting of E1, E2, and E3 enzymes constitute a complex
network that regulates a myriad of biologic processes by modifying protein substrates …

Enzymes that bind and process ubiquitin, a small 76-amino-acid protein, have been
recognized as pharmacological targets in oncology, immunological disorders, and …

Ubiquitination, a post-translational modification, regulates a vast array of fundamental
biological processes with dysregulation of the dedicated enzymes giving rise to pathologies …

SUMO is a post‐translational modifier critical for cell cycle progression and genome stability
that plays a role in tumorigenesis, thus rendering SUMO‐specific enzymes potential …

Deubiquitinating enzymes (DUBs) function to remove or cleave ubiquitin from post-
translationally modified protein substrates. There are about 100 known DUBs in the …

Ubiquitination is a post-translational modification that is involved in a plethora of cellular
processes. Target proteins can be specifically modified with a single ubiquitin (Ub) molecule …