[HTML][HTML] Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport

M Leonzino, KM Reinisch, P De Camilli - Biochimica et Biophysica Acta …, 2021 - Elsevier
The occurrence of protein mediated lipid transfer between intracellular membranes has
been known since the late 1960's. Since these early discoveries, numerous proteins …

Mitochondrial dynamics at different levels: from cristae dynamics to interorganellar cross talk

AK Kondadi, AS Reichert - Annual Review of Biophysics, 2024 - annualreviews.org
Mitochondria are essential organelles performing important cellular functions ranging from
bioenergetics and metabolism to apoptotic signaling and immune responses. They are …

[HTML][HTML] VPS13D bridges the ER to mitochondria and peroxisomes via Miro

A Guillén-Samander, M Leonzino… - The Journal of cell …, 2021 - ncbi.nlm.nih.gov
Mitochondria, which are excluded from the secretory pathway, depend on lipid transport
proteins for their lipid supply from the ER, where most lipids are synthesized. In yeast, the …

Motor proteins at the mitochondria–cytoskeleton interface

AJ Kruppa, F Buss - Journal of cell science, 2021 - journals.biologists.com
Mitochondria are multifunctional organelles that not only produce energy for the cell, but are
also important for cell signalling, apoptosis and many biosynthetic pathways. In most cell …

[HTML][HTML] FHL2 anchors mitochondria to actin and adapts mitochondrial dynamics to glucose supply

H Basu, G Pekkurnaz, J Falk, W Wei… - The Journal of cell …, 2021 - ncbi.nlm.nih.gov
Mitochondrial movement and distribution are fundamental to their function. Here we report a
mechanism that regulates mitochondrial movement by anchoring mitochondria to the F-actin …

Molecular insights into peroxisome homeostasis and peroxisome biogenesis disorders

Y Fujiki, K Okumoto, M Honsho, Y Abe - Biochimica et Biophysica Acta …, 2022 - Elsevier
Peroxisomes are single-membrane organelles essential for cell metabolism including the β-
oxidation of fatty acids, synthesis of etherlipid plasmalogens, and redox homeostasis …

Hitchhiking across kingdoms: cotransport of cargos in fungal, animal, and plant cells

JR Christensen… - Annual review of cell and …, 2022 - annualreviews.org
Eukaryotic cells across the tree of life organize their subcellular components via intracellular
transport mechanisms. In canonical transport, myosin, kinesin, and dynein motor proteins …

Spatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface

YW Chang, T Tony Yang, MC Chen, Y Liaw… - Communications …, 2023 - nature.com
Ectopic ATP synthase complex (eATP synthase), located on cancer cell surface, has been
reported to possess catalytic activity that facilitates the generation of ATP in the extracellular …

Miro: A molecular switch at the center of mitochondrial regulation

EL Eberhardt, AV Ludlam, Z Tan… - Protein …, 2020 - Wiley Online Library
The orchestration of mitochondria within the cell represents a critical aspect of cell biology.
At the center of this process is the outer mitochondrial membrane protein, Miro. Miro …

Miro GTPase domains regulate the assembly of the mitochondrial motor–adaptor complex

K Davis, H Basu, I Izquierdo-Villalba… - Life Science …, 2023 - life-science-alliance.org
Mitochondrial transport relies on a motor–adaptor complex containing Miro1, a
mitochondrial outer membrane protein with two GTPase domains, and TRAK1/2, kinesin-1 …