Macromolecules change their shape (conformation) in the process of carrying out their
functions. The imaging by cryo-electron microscopy of rapidly-frozen, individual copies of …

There is a growing interest in characterizing the structure and dynamics of large
biomolecular assemblies and their interactions within the cellular environment. A diverse …

Resolving the structural variability of proteins is often key to understanding the structure–
function relationship of those macromolecular machines. Single particle analysis using …

Atomic Force Microscopy (AFM) offers a unique opportunity to study the conformational
dynamics of proteins in near-physiological conditions at the single-molecule level. However …

Cryo-Electron Microscopy (cryo-EM) allows conformational studies of macromolecular
complexes in their close-to-native state, essential for understanding their working …