Drug discovery targeting bromodomain-containing protein 4
BRD4, the most extensively studied member of the BET family, is an epigenetic regulator
that localizes to DNA via binding to acetylated histones and controls the expression of …
that localizes to DNA via binding to acetylated histones and controls the expression of …
A patent review of BRD4 inhibitors (2013-2019)
T Lu, W Lu, C Luo - Expert Opinion on Therapeutic Patents, 2020 - Taylor & Francis
Introduction: The bromodomain-containing protein 4 (BRD4), a member of the bromodomain
and extra-terminal (BET) family, functions as an 'epigenetic reader'that binds to acetylated …
and extra-terminal (BET) family, functions as an 'epigenetic reader'that binds to acetylated …
Bicyclic bromodomain inhibitors
JF Quinn, BC Duffy, S Liu, R Wang, MX Jiang… - US Patent …, 2017 - Google Patents
2016-11-18 Assigned to ZENITH EPIGENETICS CORP. reassignment ZENITH
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Heterocyclic compounds as bromodomain inhibitors
S Liu, BC Duffy, JF Quinn, MX Jiang, R Wang… - US Patent …, 2016 - Google Patents
2015-11-03 Assigned to RESVERLOGIX CORP. reassignment RESVERLOGIX CORP.
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
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Substituted heterocycles as bromodomain inhibitors
SD Brown, CA Coburn, O Kharenko - US Patent 10,292,968, 2019 - Google Patents
US10292968B2 - Substituted heterocycles as bromodomain inhibitors - Google Patents
US10292968B2 - Substituted heterocycles as bromodomain inhibitors - Google Patents …
US10292968B2 - Substituted heterocycles as bromodomain inhibitors - Google Patents …
Substituted bicyclic compounds as bromodomain inhibitors
S Liu, JF Quinn, BC Duffy, R Wang, MX Jiang… - US Patent …, 2017 - Google Patents
2015-12-21 Assigned to ZENITH EPIGENETICS CORP. reassignment ZENITH
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Biaryl derivatives as bromodomain inhibitors
DJ Fairfax, GS Martin, JF Quinn, BC Duffy… - US Patent …, 2017 - Google Patents
2016-11-03 Assigned to RESVERLOGIX CORP. reassignment RESVERLOGIX CORP.
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Quinazolinones as bromodomain inhibitors
JF Quinn, V Khlebnikov - US Patent 9,855,271, 2018 - Google Patents
(57) ABSTRACT Int. Cl. CO7D 401/14(2006. 01) A61K 31/5377(2006. 01) C07D
401/04(2006. 01) C07D 401/12(2006. 01) C07D 405/12(2006. 01) CO7D 239/91(2006. 01) …
401/04(2006. 01) C07D 401/12(2006. 01) C07D 405/12(2006. 01) CO7D 239/91(2006. 01) …
Substituted bicyclic compounds as bromodomain inhibitors
S Liu, JF Quinn, BC Duffy, R Wang, MX Jiang… - US Patent …, 2017 - Google Patents
US9636328B2 - Substituted bicyclic compounds as bromodomain inhibitors - Google Patents
US9636328B2 - Substituted bicyclic compounds as bromodomain inhibitors - Google Patents …
US9636328B2 - Substituted bicyclic compounds as bromodomain inhibitors - Google Patents …
Cyclic amines as bromodomain inhibitors
DJ Fairfax, BC Duffy, GS Martin, JF Quinn, S Liu… - US Patent …, 2016 - Google Patents
2015-10-23 Assigned to RESVERLOGIX CORP. reassignment RESVERLOGIX CORP.
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …