Cyclometalated iridium (III) complexes as mitochondria-targeted anticancer and antibacterial agents to induce both autophagy and apoptosis
BB Chen, NL Pan, JX Liao, MY Huang, DC Jiang… - Journal of Inorganic …, 2021 - Elsevier
Mitochondrial damage will hinder the energy production of cells and produce excessive
ROS (reactive oxygen species), resulting in cell death through autophagy or apoptosis. In …
ROS (reactive oxygen species), resulting in cell death through autophagy or apoptosis. In …
Synthesis and hybrid SAR property modeling of novel cholinesterase inhibitors
A library of novel 4-{[(benzyloxy) carbonyl] amino}-2-hydroxybenzoic acid amides was
designed and synthesized in order to provide potential acetyl-and butyrylcholinesterase …
designed and synthesized in order to provide potential acetyl-and butyrylcholinesterase …
Design, synthesis, biological screening and molecular docking studies of novel multifunctional 1, 4-di (aryl/heteroaryl) substituted piperazine derivatives as potential …
BM Sanka, DM Tadesse, ET Bedada, ET Mengesha… - Bioorganic …, 2022 - Elsevier
In this paper, two series of novel multifunctional 1, 4-di (aryl/heteroaryl) substituted
piperazine derivatives (6a-d & 7a-d) were synthesized, characterized, and evaluated for …
piperazine derivatives (6a-d & 7a-d) were synthesized, characterized, and evaluated for …
Design, synthesis, and anti-PVY biological activity of 1, 3, 5-triazine derivatives containing piperazine structure
L Bai, C Wei, J Zhang, R Song - International Journal of Molecular …, 2023 - mdpi.com
In this study, a commercial agent with antivirus activity and moroxydine hydrochloride were
employed to perform a lead optimization. A series of 1, 3, 5-triazine derivatives with …
employed to perform a lead optimization. A series of 1, 3, 5-triazine derivatives with …
New unnatural Gallotannins: a way toward green antioxidants, antimicrobials and antibiofilm agents
Z Hricovíniová, Š Mascaretti, J Hricovíniová, A Čížek… - Antioxidants, 2021 - mdpi.com
Nature has been a source of inspiration for the development of new pharmaceutically active
agents. A series of new unnatural gallotannins (GTs), derived from d-lyxose, d-ribose, l …
agents. A series of new unnatural gallotannins (GTs), derived from d-lyxose, d-ribose, l …
Synthesis and Critical View on the Structure-Activity Relationships of N-(Substituted phenyl)-/N-Diphenylmethyl-piperazine-Based Conjugates as Antimycobacterial …
J Čurillová, M Pecháčová, T Padrtová, D Pecher… - Applied Sciences, 2021 - mdpi.com
This research focused on a three-step synthesis, analytical, physicochemical, and biological
evaluation of hybrid molecules 6a–g, containing a lipophilic 3-trifluoromethylphenyl moiety …
evaluation of hybrid molecules 6a–g, containing a lipophilic 3-trifluoromethylphenyl moiety …