More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis

A Frey, LP Lunding, JC Ehlers, M Weckmann… - Frontiers in …, 2020 - frontiersin.org
Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …

Dissecting lipid metabolism alterations in SARS-CoV-2

I Casari, M Manfredi, P Metharom, M Falasca - Progress in lipid research, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-
19 pandemic that has infected over a hundred million people globally. There have been …

Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein

C Toelzer, K Gupta, SKN Yadav, U Borucu… - Science, 2020 - science.org
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), represents a global crisis. Key to SARS-CoV-2 therapeutic …

A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71

X Wang, W Peng, J Ren, Z Hu, J Xu, Z Lou… - Nature structural & …, 2012 - nature.com
Abstract Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children
that can cause severe central nervous system disease and death. No vaccine or antiviral …

Poliovirus cell entry: common structural themes in viral cell entry pathways

JM Hogle - Annual Reviews in Microbiology, 2002 - annualreviews.org
▪ Abstract Structural studies of polio-and closely related viruses have provided a series of
snapshots along their cell entry pathways. Based on the structures and related kinetic …

Picornaviruses

TJ Tuthill, E Groppelli, JM Hogle… - Cell Entry by Non …, 2010 - Springer
The picornavirus family consists of a large number of small RNA viruses, many of which are
significant pathogens of humans and livestock. They are amongst the simplest of vertebrate …

Picornavirus–receptor interactions

MG Rossmann, Y He, RJ Kuhn - Trends in microbiology, 2002 - cell.com
Many picornaviruses use cell-surface molecules belonging to the immunoglobulin
superfamily (IgSF) as their cellular receptors. These molecules usually consist of tandem …

Selective inhibitors of picornavirus replication

AM De Palma, I Vliegen, E De Clercq… - Medicinal research …, 2008 - Wiley Online Library
Picornaviruses cover a large family of pathogens that have a major impact on human but
also on veterinary health. Although most infections in man subside mildly or …

The structure of coxsackievirus B3 at 3.5 Å resolution

JK Muckelbauer, M Kremer, I Minor, G Diana, FJ Dutko… - Structure, 1995 - cell.com
Abstract Background: Group B coxsackieviruses (CVBs) are etiologic agents of a number of
human diseases that range in severity from asymptomatic to lethal infections. They are …

Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C

YA Bochkov, AC Palmenberg, WM Lee, JA Rathe… - Nature medicine, 2011 - nature.com
A recently recognized human rhinovirus species C (HRV-C) is associated with up to half of
HRV infections in young children. Here we propagated two HRV-C isolates ex vivo in organ …