[HTML][HTML] Bacteriophage lambda: Early pioneer and still relevant

SR Casjens, RW Hendrix - Virology, 2015 - Elsevier
Molecular genetic research on bacteriophage lambda carried out during its golden age from
the mid-1950s to mid-1980s was critically important in the attainment of our current …

Bacteriophages and phage-inspired nanocarriers for targeted delivery of therapeutic cargos

M Karimi, H Mirshekari, SMM Basri, S Bahrami… - Advanced drug delivery …, 2016 - Elsevier
The main goal of drug delivery systems is to target therapeutic cargoes to desired cells and
to ensure their efficient uptake. Recently a number of studies have focused on designing bio …

Virus-based nanoparticles as versatile nanomachines

KJ Koudelka, AS Pitek, M Manchester… - Annual review of …, 2015 - annualreviews.org
Nanoscale engineering is revolutionizing the way we prevent, detect, and treat diseases.
Viruses have played a special role in these developments because they can function as …

Bacteriophage T4 nanoparticles for vaccine delivery against infectious diseases

P Tao, J Zhu, M Mahalingam, H Batra… - Advanced drug delivery …, 2019 - Elsevier
Subunit vaccines containing one or more target antigens from pathogenic organisms
represent safer alternatives to whole pathogen vaccines. However, the antigens by …

Phage display based biosensing: Recent advances and challenges

M Wang, S Pang, H Zhang, Z Yang, A Liu - TrAC Trends in Analytical …, 2024 - Elsevier
Phage display enables to screen probes such as peptide, antibody and nanobody with high
specificity and affinity to the target, providing excellent probes for various analytical or …

A bacteriophage T4 nanoparticle-based dual vaccine against anthrax and plague

P Tao, M Mahalingam, J Zhu, M Moayeri, J Sha… - MBio, 2018 - Am Soc Microbiol
Bacillus anthracis and Yersinia pestis, the causative agents of anthrax and plague,
respectively, are two of the deadliest pathogenic bacteria that have been used as biological …

Targeted intracellular delivery of trastuzumab using designer phage lambda nanoparticles alters cellular programs in human breast cancer cells

A Catala, M Dzieciatkowska, G Wang… - ACS …, 2021 - ACS Publications
| Several diseases exhibit a high degree of heterogeneity and diverse reprogramming of
cellular pathways. To address this complexity, additional strategies and technologies must …

Ubiquitin Engineering for Interrogating the Ubiquitin–Proteasome System and Novel Therapeutic Strategies

JQ Tang, MM Marchand, G Veggiani - Cells, 2023 - mdpi.com
Protein turnover, a highly regulated process governed by the ubiquitin–proteasome system
(UPS), is essential for maintaining cellular homeostasis. Dysregulation of the UPS has been …

Phage-like particle vaccines are highly immunogenic and protect against pathogenic coronavirus infection and disease

BJ Davenport, A Catala, SM Weston, RM Johnson… - npj Vaccines, 2022 - nature.com
The response by vaccine developers to the COVID-19 pandemic has been extraordinary
with effective vaccines authorized for emergency use in the United States within 1 year of the …

A designer nanoparticle platform for controlled intracellular delivery of bioactive macromolecules: inhibition of ubiquitin-specific protease 7 in breast cancer cells

WD McClary, A Catala, W Zhang, F Gamboni… - ACS Chemical …, 2022 - ACS Publications
Biological therapeutics represent an increasing and critical component of newly approved
drugs; however, the inability to deliver biologics intracellularly in a controlled manner …