In the current genomic revolution, the infancy life stage is the most neglected. Although
clinical genetics recognizes the value of early identification in infancy of rare genetic causes …

Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

Objective We conducted a systematic review of studies using molecular genetics and
statistical approaches to investigate the role of common genetic variation in the …

Early life is an important window of opportunity to improve health across the full lifecycle. An
accumulating body of evidence suggests that exposure to adverse stressors during early life …

As the master regulator in utero, the placenta is core to the Developmental Origins of Health
and Disease (DOHaD) hypothesis but is historically understudied. To identify placental gene …

Genomic research that targets large-scale, prospective birth cohorts constitutes an essential
strategy for understanding the influence of genetics and environment on human health …

Objective To investigate the genetic architecture of internalizing symptoms in childhood and
adolescence. Method In 22 cohorts, multiple univariate genome-wide association studies …

Abstract The Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings
together data from multiple birth cohorts from across Europe and Australia to facilitate …

Beginning with the successful sequencing of the human genome two decades ago, the
possibility of developing personalized health interventions based on one's biology has …

To identify genetic risk loci for major depressive disorder (MDD), two broad study design
approaches have been applied:(1) to maximize sample size by combining data from …