The~ 100 MB genome of C. elegans codes for~ 20,000 protein-coding genes many of which
are required for the function of the nervous system, composed of 302 neurons in the adult …

The accumulation of protein aggregates is the hallmark of many neurodegenerative
diseases. The dysregulation of protein homeostasis (or proteostasis) caused by acute …

Background Long non-protein-coding RNAs (ncRNAs) are emerging as important regulators
of cellular differentiation and are widely expressed in the brain. Results Here we show that …

Programmed cell death (PCD) is an essential component of animal development, and
aberrant cell death underlies many disorders. Understanding mechanisms that govern PCD …

Glioblastoma (GBM)-derived tumorigenic stem-like cells (GSCs) may play a key role in
therapy resistance. Previously, we reported that the mitotic kinase MELK binds and …

Depending on cell type, environmental inputs, and disease, the cells in the human body can
have widely different sizes. In recent years, it has become clear that cell size is a major …

Programmed cell death is an integral component of Caenorhabditis elegans development.
Genetic and reverse genetic studies in C. elegans have led to the identification of many …

Asymmetric positioning of the mitotic spindle before cytokinesis can produce different-sized
daughter cells that have distinct fates. Here, we found an asymmetric division in the …

Genomic aberrations of Cyclin D1 (CCND1), CDK4, and CDK6 in neuroblastoma indicate
that dysregulation of the G1 entry checkpoint is an important cell cycle aberration in this …

Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine
kinase initially found to be expressed in a wide range of early embryonic cellular stages, and …