Neurons are particularly susceptible to microtubule (MT) defects and deregulation of the MT
cytoskeleton is considered to be a common insult during the pathogenesis of …

Tauopathies are age-related neurodegenerative diseases that are characterized by the
presence of aggregates of abnormally phosphorylated tau. As tau was originally discovered …

Abstract Alzheimer's disease (AD), the most common progressive neurodegenerative
disorder, is characterized by severe cognitive decline and personality changes as a result of …

All tauopathies, including Alzheimer's disease (AD), are characterized by the intracellular
accumulation of abnormal forms of tau protein in neurons and glial cells, which negatively …

In highly polarized and elongated cells such as neurons, Tau protein must enter and move
down the axon to fulfill its biological task of stabilizing axonal microtubules. Therefore …

Tau is a multifaceted neuronal protein that stabilizes microtubules (MTs), but the mechanism
of this activity remains poorly understood. Questions include whether Tau binds MTs …

Pathological accumulation of the microtubule-associated protein tau, in the form of
neurofibrillary tangles, is a major hallmark of Alzheimer's disease, the most prevalent …

Tau is a microtubule-associated protein that plays crucial roles in physiology and
pathophysiology. In the realm of dementia, tau protein misfolding is associated with a wide …

In neurons, microtubule networks alternate between single filaments and bundled arrays
under the influence of effectors controlling their dynamics and organization. Tau is a …

Proper regulation of microtubule dynamics is essential for cell functions and involves various
microtubule-associated proteins (MAPs). Among them, end-binding proteins (EBs) …