Increasing evidence suggests that activation of the complement system plays a key role in
the pathogenesis and disease severity of Coronavirus disease 2019 (COVID-19). We used a …

The complement and hemostatic systems are complex systems, and both involve enzymatic
cascades, regulators, and cell components—platelets, endothelial cells, and immune cells …

Background Vilobelimab, an anti-C5a monoclonal antibody, was shown to be safe in a
phase 2 trial of invasively mechanically ventilated patients with COVID-19. Here, we aimed …

Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus
disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability …

Complement activation in the diseases paroxysmal nocturnal hemoglobinuria (PNH) and
atypical hemolytic uremic syndrome (aHUS) results in cytolysis and fatal thrombotic events …

Abstract C1 inhibitor (C1INH) is a multifunctional serine protease inhibitor that functions as a
major negative regulator of several biological pathways, including the contact pathway of …

The complement system is one of the oldest known tightly regulated host defense systems
evolved for efficiently functioning cell-based immune systems and antibodies. Essentially …

In the last decade, a deeper understanding of the pathogenesis of complement mediated
hemolytic disorders, such as paroxysmal nocturnal hemoglobinuria (PNH), cold agglutinin …

Patients with severe COVID-19 develop acute respiratory distress syndrome (ARDS) that
may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus was identified in
China in 2019 as the causative agent of COVID-19, and quickly spread throughout the …