Modern medicine is threatened by the global rise of antibiotic resistance, especially among
Gram-negative bacteria. Metallo-β-lactamase (MBL) enzymes are a particular concern and …

Urinary tract infections (UTIs) caused by antibiotic-resistant Gram-negative bacteria are a
growing concern due to limited treatment options. Knowledge of the common uropathogens …

P. aeruginosa is still one of the most threatening pathogens responsible for serious hospital-
acquired infections. It is intrinsically resistant to many antimicrobial agents and additional …

Objectives: To perform a pharmacokinetic/pharmacodynamic (PK/PD) analysis of continuous-
infusion (CI) fosfomycin combined with extended-infusion (EI) cefiderocol or CI ceftazidime …

Fosfomycin is being increasingly prescribed for multidrug-resistant bacterial infections. In
patients with systemic involvement, intravenous fosfomycin is usually administered as a …

Carbapenem-resistant organisms (CRO) are a major global public health threat.
Enterobacterales hydrolyze almost all β-lactams through carbapenemase production …

Multidrug resistance of bacteria has prompted intensive development work on new
medicines, but also the search for effective options among the oldest antibiotics. Although …

Objectives: The objective of this study was to explore the relationship between
pharmacokinetic/pharmacodynamic (PK/PD) target attainment of continuous-infusion (CI) …

(1) Background: To develop evidence-based algorithms for targeted antibiotic therapy of
infection-related ventilator-associated complications (IVACs) caused by non-fermenting …

Objectives Ceftazidime/avibactam is not active against MBL-producing bacteria. Combining
ceftazidime/avibactam or avibactam with aztreonam can counter the resistance of MBL …