Dedicated the memory of Akademician Valery Vasilievich Lunin, a friend, colleague,
teacher, founder and leader of the research into application of supercritical fluids in …

Micro-and nano-carrier formulations have been developed as drug delivery systems for
active pharmaceutical ingredients (APIs) that suffer from poor physico-chemical …

Prevalence and importance of polymorphism occurring in pharmaceutical compounds are
well recognized. It is of great importance to prepare and select the right form from the …

Solid-state, crystallographic purity and careful monitoring of the polymorphism of drugs and
excipients are currently an integral part of the development of modern drug delivery systems …

The present commentary aims to review the modern and innovative strategies in particle
engineering by the supercritical fluid technologies and it is principally concerned with the …

Carbamazepine microparticles were produced by the rapid expansion of supercritical
carbon dioxide solutions (RESS) method. The characteristics of the resulting particles were …

Supercritical fluid technique have been exploited in extraction, separation and crystallization
processes. In the field of pharmaceutics, supercritical carbon dioxide (scCO2) has been …

A large number of pharmaceutical compounds are orally administered to the human body. If
the drug shows a poor water-solubility and therewith low dissolution rate, a high dosage is …

Cocrystallization of naproxen racemic mixture and nicotinamide was investigated in this
work, using compressed CO2 as antisolvent. A novel racemic cocrystal structure containing …

Crystallization assisted by supercritical CO 2 has been long ago developed for micronization
purposes, but its application to fabricate cocrystals is in its infancy. In this work, the …