Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

The biology of bone healing is a rapidly developing science. Advances in transgenic and
gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal …

To date, the delivery of signaling molecules for bone regeneration has focused primarily on
factors that directly affect the bone formation pathways (osteoinduction) or that serve to …

Stem cell research has been a popular topic in the past few decades. This review aims to
discuss factors that help regulate, induce, and enhance mesenchymal stem cell (MSC) …

Abstract Purpose of Review In the process of bone fracture healing, inflammation is thought
to be an essential process that precedes bone formation and remodeling. We review recent …

Introduction Recent studies have indicated the potential of stem cell therapy in combination
with cytokines to restore the bone repair via migration and homing of stem cells to the …

Inspired by the physiological events of the “wound healing cascade”, the integration of
biomaterials and growth factors is generally accepted as an emerging and powerful strategy …

An aging population leads to increasing demand for sustained quality of life with the aid of
novel implants. Patients expect fast healing and few complications after surgery. Increased …

The gold standard for the treatment of critical-size bone defects is autologous or allogenic
bone graft. This has several limitations including donor site morbidity and the restricted …

The practice of any sport is inherently associated with the risk of musculoskeletal lesions.
We describe regenerative medicine technologies, including cellular therapies, gene …