1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

Background A large number of observational studies have reported harmful effects of low 25-
hydroxyvitamin D (25OHD) levels on non-skeletal outcomes. We performed a systematic …

Background Available evidence on the effects of vitamin D on mortality has been
inconclusive. In a recent systematic review, we found evidence that vitamin D 3 may …

This document was written with the intent to be a complete reference at the time of
publication on the topic of managing hypertension in the elderly. Given the length of the …

Background Low plasma 25-hydroxyvitamin D (25 [OH] D) concentration is associated with
high arterial blood pressure and hypertension risk, but whether this association is causal is …

The renin-angiotensin system (RAS) has a pivotal role in the maintenance of extracellular
volume homeostasis and blood pressure through complex mechanisms. Apart from the well …

The aim of the present paper was to review the most important mechanisms explaining the
possible association of vitamin D deficiency and cardiovascular diseases, focusing on …

Background: Vitamin D may modify risk for cardiometabolic outcomes (type 2 diabetes,
hypertension, or cardiovascular disease). Purpose: To examine the association between …

BACKGROUND: There is increasing evidence that, in addition to the well-known effects on
musculoskeletal health, vitamin D status may be related to a number of non-skeletal …

The aim of this study is to determine and critically evaluate the plausible relationships of
vitamin D with extra-skeletal tissues in humans. Severe vitamin D deficiency results in rickets …