Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies

J Clegg, E Soldaini, RM McLoughlin… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is one of the most important human pathogens worldwide. Its high
antibiotic resistance profile reinforces the need for new interventions like vaccines in …

Mechanisms of Immune Evasion and Bone Tissue Colonization That Make Staphylococcus aureus the Primary Pathogen in Osteomyelitis

G Muthukrishnan, EA Masters, JL Daiss… - Current osteoporosis …, 2019 - Springer
Abstract Purpose of Review Staphylococcus aureus is the primary pathogen responsible for
osteomyelitis, which remains a major healthcare burden. To understand its dominance, here …

A Comprehensive View on the Human Antibody Repertoire Against Staphylococcus aureus Antigens in the General Population

TC Meyer, S Michalik, S Holtfreter, S Weiss… - Frontiers in …, 2021 - frontiersin.org
Our goal was to provide a comprehensive overview of the antibody response to
Staphylococcus aureus antigens in the general population as a basis for defining disease …

Natural human immunity against staphylococcal protein A relies on effector functions triggered by IgG3

E Boero, AR Cruz, W Pansegrau, C Giovani… - Frontiers in …, 2022 - frontiersin.org
Staphylococcal protein A (SpA) is a multifunctional, highly conserved virulence factor of
Staphylococcus aureus. By binding the Fc portion of all human IgG subclasses apart from …

Vaccination with staphylococcal protein A protects mice against systemic complications of skin infection recurrences

AP Mandelli, G Magri, M Tortoli, S Torricelli… - Frontiers in …, 2024 - frontiersin.org
Skin and soft tissue infections (SSTIs) are the most common diseases caused by
Staphylococcus aureus (S. aureus), which can progress to threatening conditions due to …

[HTML][HTML] Toxin-neutralizing Abs are associated with improved T cell function following recovery from Staphylococcus aureus infection

M Kleinhenz, Z Li, U Chidella, W Picard, A Wolfe… - JCI insight, 2024 - ncbi.nlm.nih.gov
BACKGROUND T cell responses are impaired in Staphylococcus aureus–infected children,
highlighting a potential mechanism of immune evasion. This study tested the hypotheses …

[HTML][HTML] A bioinformatic approach to utilize a patient's antibody-secreting cells against Staphylococcus aureus to detect challenging musculoskeletal infections

G Muthukrishnan, S Soin, CA Beck, A Grier… - …, 2020 - journals.aai.org
Noninvasive diagnostics for Staphylococcus aureus musculoskeletal infections (MSKI)
remain challenging. Abs from newly activated, pathogen-specific plasmablasts in human …

Dissecting the Human Response to Staphylococcus aureus Systemic Infections

R Leuzzi, M Bodini, IP Thomsen, E Soldaini… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is a common human commensal and the leading cause of diverse
infections. To identify distinctive parameters associated with infection and colonization, we …

Immunological fingerprint of 4CMenB recombinant antigens via protein microarray reveals key immunosignatures correlating with bactericidal activity

E Bartolini, E Borgogni, M Bruttini, A Muzzi… - Nature …, 2020 - nature.com
Serogroup B meningococcus (MenB) is a leading cause of meningitis and sepsis across the
world and vaccination is the most effective way to protect against this disease. 4CMenB is a …

Impaired T-Lymphocyte Responses During Childhood Staphylococcus aureus Infection

Z Li, P Beesetty, G Gerges, M Kleinhenz… - The Journal of …, 2022 - academic.oup.com
Background Staphylococcus aureus infections are common throughout the lifespan, with
recurrent infections occurring in nearly half of infected children. There is no licensed …