The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

Glycine is one of the most important inhibitory neurotransmitters in the spinal cord and the
brainstem, and glycinergic synapses have a well-established role in the regulation of …

Neurotransmitter-gated ion channels of the Cys-loop receptor family are essential mediators
of fast neurotransmission throughout the nervous system and are implicated in many …

Ion channels are membrane proteins that act as gated pathways for the movement of ions
across cell membranes. They play essential roles in the physiology of all cells. In recent …

Inhibitory glycine receptors (GlyRs) regulate motor coordination and sensory signal
processing in spinal cord and other brain regions. GlyRs are pentameric proteins composed …

The inhibitory glycine receptor (GlyR) is a member of the ligand-gated ion channel receptor
superfamily. The GlyR comprises a pentameric complex that forms a chloride-selective …

THE neuronal nicotinic α7 (nAChR) and 5-hydroxytryptamine (5HT3) receptors1–3 are
ligand-gated ion channels with a homologous topological organization and have activation …

The effects of the antihelmintic, ivermectin, were investigated in recombinantly expressed
human α 1 homomeric and α 1 β heteromeric glycine receptors (GlyRs). At low (0.03 μm) …

Transmitter-gated ion channels mediate rapid synaptic transmission in the CNS and
constitute important targets for many neuroactive drugs. Inhibitory glycine receptors (GlyRs) …

At the turn of the century, Ehrlich (1865) from the field of immunology, and Langley (1905)
from that of pharmacology, introduced the notion that “receptive substances” combine with …