Insights into recent findings and clinical application of YAP and TAZ in cancer
Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …
[HTML][HTML] Targeting breast cancer stem cells
The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence
have been recognized for many decades. Due to their strong capacity for self-renewal and …
have been recognized for many decades. Due to their strong capacity for self-renewal and …
New insights into the ambivalent role of YAP/TAZ in human cancers
J Luo, L Deng, H Zou, Y Guo, T Tong, M Huang… - Journal of Experimental …, 2023 - Springer
Hippo signaling was first identified in Drosophila as a key controller of organ size by
regulating cell proliferation and anti-apoptosis. Subsequent studies have shown that this …
regulating cell proliferation and anti-apoptosis. Subsequent studies have shown that this …
New insights into YAP/TAZ-TEAD-mediated gene regulation and biological processes in cancer
Simple Summary The Hippo pathway is crucial for regulating cell growth, organ size, and
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …
[HTML][HTML] YAP1-TFE3-fused hemangioendothelioma: a multi-institutional clinicopathologic study of 24 genetically-confirmed cases
JK Dermawan, EM Azzato, SD Billings, KJ Fritchie… - Modern Pathology, 2021 - Elsevier
Abstract YAP1-TFE3-fused hemangioendothelioma is an extremely rare malignant vascular
tumor. We present the largest multi-institutional clinicopathologic study of YAP1-TFE3-fused …
tumor. We present the largest multi-institutional clinicopathologic study of YAP1-TFE3-fused …
Loss of CDKN2A Cooperates with WWTR1(TAZ)–CAMTA1 Gene Fusion to Promote Tumor Progression in Epithelioid Hemangioendothelioma
Purpose: Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma caused by the
WWTR1 (TAZ)–CAMTA1 (TC) gene fusion. This fusion gene has been observed in almost all …
WWTR1 (TAZ)–CAMTA1 (TC) gene fusion. This fusion gene has been observed in almost all …
TAZ/YAP fusion proteins: Mechanistic insights and therapeutic opportunities
The Hippo pathway is dysregulated in many different cancers, but point mutations in the
pathway are rare. Transcriptional co-activator with PDZ-binding motif (TAZ) and Yes …
pathway are rare. Transcriptional co-activator with PDZ-binding motif (TAZ) and Yes …
Vasculature is getting Hip (po): Hippo signaling in vascular development and disease
The Hippo signaling pathway regulates developmental organ growth, regeneration, and cell
fate decisions. Although the role of the Hippo pathway, and its transcriptional effectors YAP …
fate decisions. Although the role of the Hippo pathway, and its transcriptional effectors YAP …
Hippo Signaling at the Hallmarks of Cancer and Drug Resistance
Originally identified in Drosophila melanogaster in 1995, the Hippo signaling pathway plays
a pivotal role in organ size control and tumor suppression by inhibiting proliferation and …
a pivotal role in organ size control and tumor suppression by inhibiting proliferation and …
The TAZ-CAMTA1 fusion protein promotes tumorigenesis via connective tissue growth factor and Ras–MAPK signaling in epithelioid hemangioendothelioma
Purpose: A consistent genetic alteration in vascular cancer epithelioid
hemangioendothelioma (EHE) is the t (1; 3)(p36; q25) chromosomal translocation, which …
hemangioendothelioma (EHE) is the t (1; 3)(p36; q25) chromosomal translocation, which …