Frailty is an age-related clinical condition characterised by an increased susceptibility to
stressors and an elevated risk of adverse outcomes such as mortality. In the light of global …

Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …

As aging societies in the western world face a growing prevalence of vascular cognitive
impairment and Alzheimer's disease (AD), understanding their underlying causes and …

Defects in the DNA damage response and repair (DDR/R) network accumulate during the
aging process. Physical frailty, a state of reduced physiological function and decreased …

Recent studies exploring the relationship between DNA damage measured by the comet
assay (single-cell gel electrophoresis) and cognitive function in both animal models and …

Frailty is an age-related syndrome that drives multiple physiological system impairments in
some older adults, and its pathophysiological mechanisms remain unclear. We evaluated …

Frailty is a clinical condition closely related to aging which is characterized by a
multidimensional decline in biological reserves, a failure of physiological mechanisms and …

Background: Radiosensitivity remains an important factor affecting the clinical outcome of
radiotherapy for non-small cell lung cancer (NSCLC). Liver kinase B1 (LKB1) as a tumor …