The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …

The development of new therapeutic approaches to diseases relies on the identification of
key molecular targets involved in amplifying disease processes. One such molecule is …

Thioredoxin-interacting protein (TXNIP) is an α-arrestin family protein that is induced in
response to glucose elevation. It has been shown to provide a negative feedback loop to …

Growth factors, such as insulin, can induce both acute and long-term glucose uptake into
cells. Apart from the rapid, insulin-induced fusion of glucose transporter (GLUT) 4 storage …

Purpose Cancer, a major public health problem, exhibits significant redox alteration.
Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting …

Significance: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D
upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by …

Chronic hyperglycemia (HG)-associated reactive oxygen/nitrogen species (ROS/RNS)
stress and low grade inflammation are considered to play critical roles in the development of …

Thioredoxin-interacting protein (Txnip) has important functions in regulating cellular
metabolism including glucose utilization; the expression of the Txnip gene is sensitive to the …

Sequencing data from 10 species show that a plant hexokinase (HXK) family contains 5–11
genes. Functionally, a given family can include metabolic catalysts, glucose signaling …

抄録 Thioredoxin binding protein− 2/thioredoxin interacting protein is an α-arrestin protein
that has attracted much attention as a multifunctional regulator. Thioredoxin binding protein …