Breast cancer metastasis: mechanisms and therapeutic implications

M Park, D Kim, S Ko, A Kim, K Mo, H Yoon - International journal of …, 2022 - mdpi.com
Breast cancer is the most common malignancy in women worldwide. Metastasis is the
leading cause of high mortality in most cancers. Although predicting the early stage of breast …

Epithelial-mesenchymal plasticity in cancer progression and metastasis

W Lu, Y Kang - Developmental cell, 2019 - cell.com
Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-
epithelial transition (MET), are fundamental processes in embryonic development and tissue …

RETRACTED ARTICLE: RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail

X Lin, G Chai, Y Wu, J Li, F Chen, J Liu, G Luo… - Nature …, 2019 - nature.com
Abstract N6-Methyladenosine (m6A) modification has been implicated in the progression of
several cancers. We reveal that during epithelial-mesenchymal transition (EMT), one …

Lineage plasticity in cancer: a shared pathway of therapeutic resistance

Á Quintanal-Villalonga, JM Chan, HA Yu… - Nature reviews Clinical …, 2020 - nature.com
Lineage plasticity, the ability of cells to transition from one committed developmental
pathway to another, has been proposed as a source of intratumoural heterogeneity and of …

Regulation of EMT in colorectal cancer: a culprit in metastasis

T Vu, PK Datta - Cancers, 2017 - mdpi.com
Epithelial to mesenchymal transition (EMT) is a process during which cells lose their
epithelial characteristics, for instance cell polarity and cell–cell contact, and gain …

E-cadherin: Its dysregulation in carcinogenesis and clinical implications

SHM Wong, CM Fang, LH Chuah, CO Leong… - Critical reviews in …, 2018 - Elsevier
E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …

Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications

SJ Serrano-Gomez, M Maziveyi, SK Alahari - Molecular cancer, 2016 - Springer
The epithelial to mesenchymal transition (EMT) is a biological process in which a non-motile
epithelial cell changes to a mesenchymal phenotype with invasive capacities. This …

Molecular mechanisms of epithelial–mesenchymal transition

S Lamouille, J Xu, R Derynck - Nature reviews Molecular cell biology, 2014 - nature.com
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as
epithelial–mesenchymal transition (EMT), is integral in development, wound healing and …

Regulatory networks defining EMT during cancer initiation and progression

BD Craene, G Berx - Nature Reviews Cancer, 2013 - nature.com
Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during
development, but is an unintentional behaviour of cells during cancer progression. The EMT …

The epigenetics of epithelial-mesenchymal plasticity in cancer

WL Tam, RA Weinberg - Nature medicine, 2013 - nature.com
During the course of malignant cancer progression, neoplastic cells undergo dynamic and
reversible transitions between multiple phenotypic states, the extremes of which are defined …