Base flipping is the phenomenon whereby a base in normal B-DNA is swung completely out
of the helix into an extrahelical position. It was discovered in 1994 when the first co-crystal …

Phenotypic diversity is shaped by both genetic and epigenetic mechanisms that program
tissue specific patterns of gene expression. Cells, including neurons, undergo massive …

Previous X-ray crystallographic studies have revealed that the catalytic domain of a DNA
methyltransferase (Mtase) generating C5-methylcytosine bears a striking structural similarity …

Metabolism and nutrition have a significant role in epigenetic modifications such as DNA
methylation, which can influence gene expression. Recently, it has been suggested that …

11724, USA sites are almost identical and the essential catalytic amino acids coincide. The
comparable protein folding and the existence of equivalent amino acids in similar secondary …

Enzymatic methylation of DNA plays important roles in both prokaryotes and eukaryotes.
Structural study of the Hhal DNA methyltransferase has provided considerable insight into …

DNA-protein cross-links (DPCs) present a formidable obstacle to cellular processes
because they are" superbulky" compared with the majority of chemical adducts. Elimination …

The refined crystal structures ofHhaI methyltransferase complexed with cognate
unmethylated or methylated DNA together withS-adenosyl-L-homocysteine, along with the …

Kinetic and binding studies involving a model DNA cytosine-5-methyltransferase, M. HhaI,
and a 37-mer DNA duplex containing a single hemimethylated target site were applied to …

Abstract ABSTRACT The (cytosine-5) DNA methyltransferase M. Hha l causes its target
cytosine base to be flipped completelyout of the DNA helix upon binding. We have …