Pluripotent stem cells show a remarkable ability to self-organize and differentiate in vitro in
three-dimensional aggregates, known as organoids or organ spheroids, and to recapitulate …

Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …

Human stem-cell-derived models provide the promise of accelerating our understanding of
brain disorders, but not knowing whether they possess the ability to mature beyond mid-to …

Autism spectrum disorder (ASD) has a complex genetic architecture involving contributions
from both de novo and inherited variation. Few studies have been designed to address the …

Components of the proteostasis network malfunction in aging, and reduced protein quality
control in neurons has been proposed to promote neurodegeneration. Here, we investigate …

Sporadic Alzheimer's disease (AD) exclusively affects elderly people. Using direct
conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age …

Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the
incidence, symptoms and treatment of MDD all point toward major sex differences, the …

The differentiation of pluripotent stem cells in three-dimensional cultures can recapitulate
key aspects of brain development, but protocols are prone to variable results. Here we …

The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …

The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …