Melatonin has been shown to protect against oxidative stress in various, highly divergent
experimental systems. There are many reasons for its remarkable protective potential …

It was recently discovered that mammalian skin can produce serotonin and transform it into
melatonin. Pathways for the biosynthesis and biodegradation of serotonin and melatonin …

Melatonin, a ubiquitous methoxyindole, is produced by and metabolized in the skin.
Melatonin affects skin functions and structures through actions mediated by cell-surface and …

Melatonin has been experimentally implicated in skin functions such as hair growth cycling,
fur pigmentation, and melanoma control, and melatonin receptors are expressed in several …

The toxicity of gentamicin (GEN) in the kidney seems to relate to the generation of reactive
oxygen species (ROS). Caffeic acid phenethyl ester (CAPE) has been demonstrated to have …

Melatonin, one of the evolutionarily most ancient, highly conserved and most pleiotropic
hormones still operative in man, couples complex tissue functions to defined changes in the …

The random-pattern skin flap is a crucial technique in reconstructive surgery and flap
necrosis caused by ischemia/reperfusion injury is a major postoperative complication …

Pulmonary hypertension of the newborn (PHN) constitutes a critical condition with severe
cardiovascular and neurological consequences. One of its main causes is hypoxia during …

Background: Multi-territory perforator flaps are a reconstructive measure for repairing large
soft tissue defects caused by tumors or trauma. However, the use of these flaps in clinical …

Objective Random skin flaps are often placed by plastic surgeons to treat limb deformities
and dysfunction. Nesfatin-1 (NES) is a peptide that exerts angiogenic, anti-inflammatory, and …