Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron loss and the
formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is …

Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …

The human brain consumes 20% of the total basal oxygen (O 2) budget to support ATP
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …

A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

In the CNS, iron in several proteins is involved in many important processes such as oxygen
transportation, oxidative phosphorylation, myelin production, and the synthesis and …

This is the fifth in the series of reviews developed as part of the Biomarkers of Nutrition for
Development (BOND) program. The BOND Iron Expert Panel (I-EP) reviewed the extant …

Brain iron homeostasis is increasingly recognized as a potential target for the development
of drug therapies for aging‐related disorders. Dysregulation of iron metabolism associated …

Docosahexaenoic acid (DHA) is the predominant omega-3 (n-3) polyunsaturated fatty acid
(PUFA) found in the brain and can affect neurological function by modulating signal …

During the last five years ultra-high-field magnetic resonance imaging (MRI) has enabled an
unprecedented view of living human brain. Brain tissue contrast in most MRI sequences is …

Quantitative susceptibility mapping (QSM) is a novel technique which allows determining the
bulk magnetic susceptibility distribution of tissue in vivo from gradient echo magnetic …