In mammals, the neuroendocrine system, which includes the communication between the
hypothalamus and the pituitary, plays a major role in controlling body growth and cellular …

Since its discovery nearly a century ago, over 100,000 studies of growth hormone (GH) have
investigated its structure, how it interacts with the GH receptor and its multiple actions. These …

Hypertrophic chondrocytes are the master regulators of endochondral ossification; however,
their ultimate cell fates cells remain largely elusive due to their transient nature. Historically …

Studies in multiple species indicate that reducing growth hormone (GH) action enhances
healthy lifespan. In fact, GH receptor knockout (GHRKO) mice hold the Methuselah prize for …

Growth hormone (GH) is a pleiotropic hormone that coordinates an array of physiological
processes, including effects on bone, muscle, and fat, ultimately resulting in growth …

Much of our understanding of GH's action stems from animal models and the generation and
characterization of genetically altered or modified mice. Manipulation of genes in the …

Obesity and metabolic-related diseases, among which diabetes, are prominent public health
challenges of the 21st century. It is now well acknowledged that pollutants are a part of the …

Obesity is a growing public health problem worldwide, and GH and IGF-1 have been studied
as potential therapeutic targets for managing this condition. This review article aims to …

Abstract Background/Objectives Childhood obesity, particularly in girls, is linked to early
puberty onset, heightening risks for adult-onset diseases. Addressing childhood obesity and …

Adipose is a key tissue regulating energy homeostasis. In states of obesity, caloric intake
exceeds energy expenditure, thereby accelerating lipid accumulation with ongoing …