Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo

P Kumar, JN Kizhakkedathu, SK Straus - Biomolecules, 2018 - mdpi.com
Antibiotic resistance is projected as one of the greatest threats to human health in the future
and hence alternatives are being explored to combat resistance. Antimicrobial peptides …

Animal venoms as antimicrobial agents

RP Samy, BG Stiles, OL Franco, G Sethi… - Biochemical …, 2017 - Elsevier
Hospitals are breeding grounds for many life-threatening bacteria worldwide. Clinically
associated gram-positive bacteria such as Staphylococcus aureus/methicillin-resistant S …

Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn (15–34), antimicrobial peptides from rattlesnake venom

C Pérez-Peinado, SA Dias, MM Domingues… - Journal of Biological …, 2018 - ASBMB
Crotalicidin (Ctn), a cathelicidin-related peptide from the venom of a South American
rattlesnake, possesses potent antimicrobial, antitumor, and antifungal properties. Previously …

Exploring the potential of bioactive peptides: From natural sources to therapeutics

K Purohit, N Reddy, A Sunna - International Journal of Molecular …, 2024 - mdpi.com
Bioactive peptides, specific protein fragments with positive health effects, are gaining
traction in drug development for advantages like enhanced penetration, low toxicity, and …

Biodegradable polymers and polymer composites with antibacterial properties

A Smola-Dmochowska, K Lewicka, A Macyk… - International journal of …, 2023 - mdpi.com
Antibiotic resistance is one of the greatest threats to global health and food security today. It
becomes increasingly difficult to treat infectious disorders because antibiotics, even the …

Antibiofilm Activity on Candida albicans and Mechanism of Action on Biomembrane Models of the Antimicrobial Peptide Ctn[15–34]

FLL Aguiar, NC Santos… - International journal of …, 2020 - mdpi.com
Ctn [15–34], the C-terminal fragment of crotalicidin, an antimicrobial peptide from the South
American rattlesnake Crotalus durissus terrificus venom, displays remarkable anti-infective …

Cell-penetrating peptides derived from animal venoms and toxins

G Rádis-Baptista - Toxins, 2021 - mdpi.com
Cell-penetrating peptides (CPPs) comprise a class of short polypeptides that possess the
ability to selectively interact with the cytoplasmic membrane of certain cell types, translocate …

Snake venom cathelicidins as natural antimicrobial peptides

EN De Barros, RM Gonçalves, MH Cardoso… - Frontiers in …, 2019 - frontiersin.org
Bioactive small molecules isolated from animals, plants, fungi and bacteria, including natural
antimicrobial peptides, have shown great therapeutic potential worldwide. Among these …

Hitchhiking with nature: snake venom peptides to fight cancer and superbugs

C Pérez-Peinado, S Defaus, D Andreu - Toxins, 2020 - mdpi.com
For decades, natural products in general and snake venoms (SV) in particular have been a
rich source of bioactive compounds for drug discovery, and they remain a promising …

Snake venom peptides and low mass proteins: molecular tools and therapeutic agents

JR Almeida, LM Resende, RK Watanabe… - Current medicinal …, 2017 - ingentaconnect.com
Snake venoms are natural sources of biologically active molecules that are able to act
selectively and specifically on different cellular targets, modulating physiological functions …