It is well established that alterations in phosphate metabolism have a profound effect on
hard and soft tissues of the oral cavity. The present-day clinical form of osteonecrosis of the …

Osteonecrosis of the jaw (ONJ) was defined as exposed, necrotic bone in the maxillofacial
region for at least 8 weeks in patients receiving an antiresorptive medication for primary or …

Abstract The bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2, BPs) were first shown to
inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed …

Background: Invasive dental treatment in patients exposed to antiresorptive and
antiangiogenic drugs can cause medication-related osteonecrosis of the jaw (MRONJ) …

Objectives A central role of infections in the treatment of MRONJ patients is widely accepted.
An investigation of the MRONJ lesions' biofilms as potential pathogens seems logical …

Medication-related osteonecrosis of the jaw (MRONJ) is a growing problem without an
effective treatment, presenting as necrotic bone sections exposed via lesions in the …

Tissue engineering of bone and oral mucosa have been extensively studied independently.
The aim of this study was to develop and investigate a novel combination of bone and oral …

A bone imaging toolkit of 21 fluorescent probes with variable spectroscopic properties, bone
mineral binding affinities, and antiprenylation activities has been created, including a novel …

Background: Bisphosphonates are drugs commonly used for the medication and prevention
of diseases caused by decreased mineral density. Despite such important medicinal use …

Objectives The aim of this work was to combine engineered hard and soft tissue, adopting a
new method for interfacial adhesion of osteo-mucosal construct. We hypothesized that the …