Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-
rich semaphorin protein domains, that have important roles in a variety of tissues. Humans …

Coupling during bone remodeling refers to the spatial and temporal coordination of bone
resorption with bone formation. Studies have assessed the subtle interactions between …

Despite genetic evidence establishing angiopoietin-1 (Ang-1) as an essential regulator of
vascular development, the molecular mechanisms underlying Ang-1 function are almost …

In many CNS pathways, target innervation occurs by axon branching rather than extension
of the primary growth cone into targets. To investigate mechanisms of branch formation, we …

Semaphorins are a large family of secreted and membrane-bound molecules that were
initially implicated in the development of the nervous system and in axon guidance. More …

Axon guidance requires signal transduction of extracellular cues through the plasma
membrane for directional motility. Here we present evidence that cholesterol-and …

The conversion of guanosine triphosphate (GTP) to guanosine diphosphate (GDP) and
inorganic phosphate (P i) by guanine nucleotide binding proteins (GNBPs) is a fundamental …

▪ Abstract Immunoglobulin superfamily (IgSF) proteins are implicated in diverse steps of
brain development, including neuronal migration, axon pathfinding, target recognition and …

Previous studies showed that the serine/threonine kinase Unc51. 1 is one of the earliest
genes in neuronal differentiation and is required for granule cell axon formation. To examine …

Extracellular cues direct axon extension by regulating growth cone morphology. The netrin-1
receptor deleted in colorectal cancer (DCC) is required for commissural axon extension to …