Tobacco smoking remains without a doubt one of the leading causes of premature death
worldwide. In combination with conventional protocols for smoking cessation, e-cigarettes …

The adverse effects to humans and environment of only few chemicals are well known.
Absorption, distribution, metabolism, and excretion (ADME) are the steps of pharmaco …

Activities of xenobiotic-metabolizing enzymes have been measured with various in vitro and
in vivo methods, such as spectrophotometric, fluorometric, mass spectrometric, and …

Abstract Six series of 4-(benzo [c][1, 2, 5] thiadiazol-5-yl)-3 (5)-(6-methylpyridin-2-yl)-
pyrazoles 18a–d, 19a–d, 22a–d and 3 (5)-(6-methylpyridin-2-yl)-4-(thieno [3, 2,-c]-pyridin-2 …

An efficient and straightforward synthesis of isoquinolines is reported from internal alkenyl
boronic esters, easily prepared from the corresponding 1, 2-bis (boronates), via a sequential …

Transforming growth factor (TGF-β), a key mediator of tumor growth and metastasis, has
been recognized as an important cancer drug target. A series of benzo [c][1, 2, 5] thiadiazol …

Binding site flexibility and dynamics strongly affect the ability of proteins to accommodate
substrates and inhibitors. The significance of these properties is particularly pronounced for …

A photoredox-mediated, regiospecific alkyl addition reaction of (hetero) arene-fused
thiophenes has been developed, employing bench-stable N-benzoyl alkyl-sulfinamides as …

Nicotine is the primary psychoactive chemical in both traditional and electronic cigarettes (e-
cigarettes). Nicotine levels in both traditional cigarettes and e-cigarettes are an important …

Information about the metabolism of compounds is essential in drug discovery and
development, risk assessment of chemicals and further development of predictive methods …