Antioxidant, Anti-Inflammatory and Cytotoxic Activity of Phenolic Compound Family Extracted from Raspberries (Rubus idaeus): A General Review

AV Lopez-Corona, I Valencia-Espinosa… - Antioxidants, 2022 - mdpi.com
Raspberries (Rubus idaeus) possess a wide phenolic family profile; this serves the role of
self-protection for the plant. Interest in these compounds have significantly increased, since …

Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health …

FA Tomás‐Barberán… - Molecular nutrition & …, 2017 - Wiley Online Library
Urolithins are dibenzo [b, d] pyran‐6‐one derivatives that are produced by the human gut
microbiota from ellagitannins and ellagic acid (EA). These metabolites are much better …

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

D Ryu, L Mouchiroud, PA Andreux, E Katsyuba… - Nature medicine, 2016 - nature.com
The biological effects of urolithins remain poorly characterized, despite wide-spread human
exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which …

Understanding the molecular mechanisms of the interplay between herbal medicines and gut microbiota

J Xu, HB Chen, SL Li - Medicinal Research Reviews, 2017 - Wiley Online Library
Herbal medicines (HMs) are much appreciated for their significant contribution to human
survival and reproduction by remedial and prophylactic management of diseases. Defining …

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice

Z Gong, J Huang, B Xu, Z Ou, L Zhang, X Lin… - Journal of …, 2019 - Springer
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder
characterized by an abnormal accumulation of amyloid-β (Aβ) plaques, neuroinflammation …

The impact of ellagitannins and their metabolites through gut microbiome on the gut health and brain wellness within the gut–brain axis

R Banc, ME Rusu, L Filip, DS Popa - Foods, 2023 - mdpi.com
Ellagitannins (ETs) are a large group of bioactive compounds found in plant-source foods,
such as pomegranates, berries, and nuts. The consumption of ETs has often been …

Natural polyphenols: a potential prevention and treatment strategy for metabolic syndrome

S Wang, Q Du, X Meng, Y Zhang - Food & Function, 2022 - pubs.rsc.org
Metabolic syndrome (MS) is the term for a combination of hypertension, dyslipidemia, insulin
resistance, and central obesity as factors leading to cardiovascular and metabolic disease …

Ellagic acid‐derived urolithins as modulators of oxidative stress

J Djedjibegovic, A Marjanovic… - … medicine and cellular …, 2020 - Wiley Online Library
Oxidative stress is a state of excess of prooxidative species relative to the antioxidant
defenses (enzymatic and nonenzymatic) in a living organism. The consequence of this …

Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice

B Xia, XC Shi, BC Xie, MQ Zhu, Y Chen, XY Chu… - PLoS …, 2020 - journals.plos.org
Obesity leads to multiple health problems, including diabetes, fatty liver, and even cancer.
Here, we report that urolithin A (UA), a gut-microflora–derived metabolite of pomegranate …

Synergic interactions between polyphenols and gut microbiota in mitigating inflammatory bowel diseases

H Li, LM Christman, R Li, L Gu - Food & function, 2020 - pubs.rsc.org
Inflammatory bowel diseases (IBD) are a group of chronic and recurring inflammatory
conditions in the colon and intestine. Their etiology is not fully understood but involves the …