Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

ABSTRACT A regular heartbeat is essential for maintaining the homeostasis of the
vertebrate body. However, environmental pollutants, oxygen deficiency and extreme …

In the adult heart, acute adaptation of electrical and mechanical activity to changes in
mechanical load occurs via feedback processes known as “mechano-electric coupling” and …

Aim Bradyarrhythmias result from inhibition of automaticity, prolonged repolarization, or slow
conduction in the heart. The ERG channels mediate the repolarizing current IKr in the …

Popeye domain-containing (POPDC) proteins selectively bind cAMP and mediate cellular
responses to sympathetic nervous system (SNS) stimulation. The first discovered human …

The HCN4 channel is essential for heart rate regulation in vertebrates by generating
pacemaker potentials in the sinoatrial node. HCN4 channel abnormality may cause …

Tropical teleost fish Danio rerio is increasingly used as a model object for
electrophysiological studies of human cardiac physiology and pathology. D. rerio is …

Diabetes mellitus can induce substantial damage to the conduction system of the heart,
especially the sinoatrial node. This is due to hyperglycemia leading to bradyarrhythmia. DM …

1 BACKGROUND Sensitive, robust, and cost-efficient methods for studies leading to new
insights into genetically-mediated heart rhythm disturbances and their treatments are …