A surprising finding of recent studies in mouse is the dominance of widespread movement-
related activity throughout the brain, including in early sensory areas. In awake subjects …

Background Patients with obsessive-compulsive disorder (OCD) display disrupted
performance and abnormal lateral orbitofrontal cortex (LOFC) activity during reversal …

Compulsive behaviors are a hallmark symptom of obsessive compulsive disorder (OCD).
Striatal hyperactivity has been linked to compulsive behavior generation in correlative …

Self-grooming is an innate, naturalistic behavior found in a wide variety of organisms. The
control of rodent grooming has been shown to be mediated by the dorsolateral striatum …

Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder that often presents
with psychiatric conditions, including autism spectrum disorder (ASD). ASD is characterized …

Synaptic plasticity, the experience-induced change in connections between neurons,
underlies learning and memory in the brain. Most of our understanding of synaptic plasticity …

Compulsive behaviors are a hallmark symptom of obsessive compulsive disorder (OCD).
Striatal hyperactivity has been linked to compulsive behavior generation in correlative …

The orbitofrontal cortex–ventromedial striatum (OFC–VMS) circuitry is widely believed to
drive compulsive behavior. Hyperactivating this pathway in inbred mice produces excessive …

Vertebrate brains evolved to facilitate a diverse array of behaviors and internal cognitive
processes. Theories of neural function have proposed that neural computation is organized …

Background Patients with obsessive-compulsive disorder (OCD) display disrupted
performance and abnormal lateral orbitofrontal cortex (LOFC) activity during reversal …