Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is
morphologically and mechanistically different from other forms of cell death, plays a vital role …

Brain iron accumulation has been found to accelerate disease progression in amyloid-β (Aβ)
positive Alzheimer patients, though the mechanism is still unknown. Microglia have been …

Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Abstract See Derry and Kent (doi: 10.1093/awx167) for a scientific commentary on this
article. The large variance in cognitive deterioration in subjects who test positive for amyloid …

We present a review of the characterization of healthy brain aging using MRI with an
emphasis on morphology, lesions, and quantitative MR parameters. A scope review found …

A growing body of evidence suggests that the dysregulation of neuronal iron may play a
critical role in Alzheimer's disease. Recent MRI studies have established a relationship …

Significance: Essential metals such as copper, iron, manganese, and zinc play a role as
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …

Background Dementia is common in Parkinson's disease (PD) but measures that track
cognitive change in PD are lacking. Brain tissue iron accumulates with age and co-localises …

The complexity of Alzheimer's disease (AD) complicates the search for effective treatments.
While the key roles of pathologically modified proteins has occupied a central role in …