Simple Summary Hepatocellular carcinoma (HCC) is a global health challenge. Hepatitis
virus infection (including HBV, HCV and HDV) is one of the major risk factors for HCC …

Approved anticancer drugs typically face challenges due to their narrow therapeutic window,
primarily because of high systemic toxicity and limited selectivity for tumors. Prodrugs are …

Exosomes, membrane-bound nanosized vesicles of biologic origin, are known to contain
various molecules, eg, proteins, lipids, and nucleic acids, which contribute to the exosomes' …

Background Hepatocellular carcinoma (HCC) is one of the most common malignancies in
the world, with high incidence, high malignancy, and low survival rate. Cuproptosis is a …

Highlights•Metabolic procedures of a nucleoside anticancer drug are summarized.•
Anticancer properties of newly synthesized nucleoside analogs are introduced.•Synthetic …

Background and aim: Hepatocellular carcinoma (HCC) is a significant complication of
hepatitis B and still poses a global public health concern. This systematic review and meta …

To understand the solvation mechanism of gemcitabine in pure and mixed solvents, its mole
fraction solubility was investigated. The results show that the maximum solubility in mole …

Gemcitabine is an antimetabolite drug approved for the treatment of various cancers.
However, its use is limited due to several issues such as stability, toxicity and drug …

Anticancer drug administration is currently associated with high toxicity and a lack of tumor
specificity. Prodrugs are being developed to improve the therapeutic index of these drugs by …

Hepatitis C virus (HCV) has caused a considerable threat to human health. To date, no
treatments are without side effects. The proteins and RNA associated with HCV have …