Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials

CM Zipser, JJ Cragg, JD Guest, MG Fehlings… - The Lancet …, 2022 - thelancet.com
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …

The neuroanatomical–functional paradox in spinal cord injury

K Fouad, PG Popovich, MA Kopp… - Nature Reviews …, 2021 - nature.com
Although lesion size is widely considered to be the most reliable predictor of outcome after
CNS injury, lesions of comparable size can produce vastly different magnitudes of functional …

Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging

G David, S Mohammadi, AR Martin… - Nature Reviews …, 2019 - nature.com
Pathophysiological changes in the spinal cord white and grey matter resulting from injury
can be observed with MRI techniques. These techniques provide sensitive markers of …

MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers

P Freund, M Seif, N Weiskopf, K Friston… - The Lancet …, 2019 - thelancet.com
Traumatic spinal cord injury occurs when an external physical impact damages the spinal
cord and leads to permanent neurological dysfunction and disability, and it is associated …

Prognostic value of tissue bridges in cervical spinal cord injury: a longitudinal, multicentre, retrospective cohort study

D Pfyffer, AC Smith, KA Weber, A Grillhoesl… - The Lancet …, 2024 - thelancet.com
Background The accuracy of prognostication in patients with cervical spinal cord injury (SCI)
needs to be improved. We aimed to explore the prognostic value of preserved spinal tissue …

Guidelines for the conduct of clinical trials in spinal cord injury: Neuroimaging biomarkers

M Seif, CAM Gandini Wheeler-Kingshott… - Spinal Cord, 2019 - nature.com
Traumatic spinal cord injury (SCI) leads to immediate neuronal and axonal damage at the
focal injury site and triggers secondary pathologic series of events resulting in sensorimotor …

Finger somatotopy is preserved after tetraplegia but deteriorates over time

S Kikkert, D Pfyffer, M Verling, P Freund, N Wenderoth - Elife, 2021 - elifesciences.org
Previous studies showed reorganised and/or altered activity in the primary sensorimotor
cortex after a spinal cord injury (SCI), suggested to reflect abnormal processing. However …

Spinal cord imaging markers and recovery of volitional leg movement with spinal cord epidural stimulation in individuals with clinically motor complete spinal cord …

E Rejc, AC Smith, KA Weber, B Ugiliweneza… - Frontiers in systems …, 2020 - frontiersin.org
Previous studies have shown that epidural stimulation of the lumbosacral spinal cord (scES)
can re-enable lower limb volitional motor control in individuals with chronic, clinically motor …

Sciseg: Automatic segmentation of intramedullary lesions in spinal cord injury on t2-weighted mri scans

E Naga Karthik, J Valošek, AC Smith… - Radiology: Artificial …, 2024 - pubs.rsna.org
Purpose To develop a deep learning tool for the automatic segmentation of the spinal cord
and intramedullary lesions in spinal cord injury (SCI) on T2-weighted MRI scans. Materials …

Predictive value of midsagittal tissue bridges on functional recovery after spinal cord injury

D Pfyffer, K Vallotton, A Curt… - … and neural repair, 2021 - journals.sagepub.com
Background The majority of patients with spinal cord injury (SCI) have anatomically
incomplete lesions and present with preserved tissue bridges, yet their outcomes vary …