Amyotrophic lateral sclerosis is a fatal neurodegenerative disease. The discovery of genes
associated with amyotrophic lateral sclerosis, commencing with SOD1 in 1993, started fairly …

Glycosylation, the addition of glycans or carbohydrates to proteins, lipids, or other glycans, is
a complex post-translational modification that plays a crucial role in cellular function. It is …

Astrocytes are the most abundant cells in the brain. They have many important functions in
the central nervous system (CNS), including the maintenance of glutamate and ion …

The Golgi is a membrane-bound organelle that is essential for protein and lipid biosynthesis.
It represents a central trafficking hub that sorts proteins and lipids to various destinations or …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) primarily affect the
motor and frontotemporal areas of the brain, respectively. These disorders share clinical …

Motor neuron diseases (MNDs) are etiologically and biologically heterogeneous diseases.
The pathobiology of motor neuron degeneration is still largely unknown, and no effective …

One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
degeneration of motor neurons in the brain and spinal cord. The causes of ALS are not fully …

Biofluid analysis by optical spectroscopy techniques is attracting considerable interest due
to its potential to revolutionize diagnostics and precision medicine, particularly for …

Astrocytes are the most abundant glial cell in the central nervous system and are involved in
multiple processes including metabolic homeostasis, blood brain barrier regulation and …