TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
Tolerogenic dendritic cells in autoimmunity and inflammatory diseases
O Morante-Palacios, F Fondelli, E Ballestar… - Trends in …, 2021 - cell.com
Dendritic cells (DCs), the most efficient antigen-presenting cells, are necessary for the
effective activation of naïve T cells. DCs can also acquire tolerogenic functions in vivo and in …
effective activation of naïve T cells. DCs can also acquire tolerogenic functions in vivo and in …
β-Glucan reverses the epigenetic state of LPS-induced immunological tolerance
Innate immune memory is the phenomenon whereby innate immune cells such as
monocytes or macrophages undergo functional reprogramming after exposure to microbial …
monocytes or macrophages undergo functional reprogramming after exposure to microbial …
Sensitivity of transcription factors to DNA methylation
Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …
states throughout organism development. Epigenetics modifications, such as DNA …
Active DNA demethylation promotes cell fate specification and the DNA damage response
Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to
neuronal enhancers, but the source of this endogenous damage remains unclear. Using two …
neuronal enhancers, but the source of this endogenous damage remains unclear. Using two …
Transcription factors drive Tet2-mediated enhancer demethylation to reprogram cell fate
Here, we report DNA methylation and hydroxymethylation dynamics at nucleotide resolution
using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs) …
using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs) …
Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells
O Morante-Palacios, G Godoy-Tena… - Nucleic acids …, 2022 - academic.oup.com
Dendritic cells (DCs), the most potent antigen-presenting cells, are necessary for effective
activation of naïve T cells. DCs' immunological properties are modulated in response to …
activation of naïve T cells. DCs' immunological properties are modulated in response to …
[HTML][HTML] Tet2 restrains inflammatory gene expression in macrophages
Tet methylcytosine dioxygenase 2 (TET2) is one of the earliest and most frequently mutated
genes in clonal hematopoiesis of indeterminate potential (CHIP) and myeloid cancers …
genes in clonal hematopoiesis of indeterminate potential (CHIP) and myeloid cancers …
Small-magnitude effect sizes in epigenetic end points are important in children's environmental health studies: the children's environmental health and disease …
Background: Characterization of the epigenome is a primary interest for children's
environmental health researchers studying the environmental influences on human …
environmental health researchers studying the environmental influences on human …
Epigenetic control of myeloid cell differentiation, identity and function
Myeloid cells are crucial effectors of the innate immune response and important regulators of
adaptive immunity. The differentiation and activation of myeloid cells requires the timely …
adaptive immunity. The differentiation and activation of myeloid cells requires the timely …