Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …

Glucose in chronic excess causes toxic effects on structure and function of organs, including
the pancreatic islet. Multiple biochemical pathways and mechanisms of action for glucose …

In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to pancreatic β
cells, causing impaired insulin secretion. IL-1β is a proinflammatory cytokine acting during …

Increasing evidences have suggested that oxidative stress plays a major role in the
pathogenesis of diabetes mellitus (DM). Oxidative stress also appears to be the pathogenic …

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we
assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate …

It is well established that regular physiological stimulation by glucose plays a crucial role in
the maintenance of the β-cell differentiated phenotype. In contrast, prolonged or repeated …

Glucotoxicity and lipotoxicity contribute to the impaired β-cell function observed in type 2
diabetes. Here we examine the effect of saturated and monounsaturated fatty acids at …

Dietary antioxidant compounds such as bioflavonoids may offer some protection against the
early stage of diabetes mellitus and the development of complications. We investigated the …

In autoimmune type 1 diabetes, Fas–to–Fas-ligand (FasL) interaction may represent one of
the essential pro-apoptotic pathways leading to a loss of pancreatic β-cells. In the advanced …

Loss of β-cell mass and function raises a concern regarding the application of sulfonylureas
for the treatment of type 2 diabetes because previous studies have shown that agents that …