Inwardly rectifying K+ channels 4.1 and 5.1 (Kir4.1/Kir5.1) in the renal distal nephron

WH Wang, DH Lin - American Journal of Physiology-Cell …, 2022 - journals.physiology.org
The inwardly rectifying potassium channel (Kir) 4.1 (encoded by KCNJ10) interacts with Kir5.
1 (encoded by KCNJ16) to form a major basolateral K+ channel in the renal distal …

Role of inwardly rectifying K+ channel 5.1 (Kir5. 1) in the regulation of renal membrane transport

DH Lin, XP Duan, JY Zheng… - Current opinion in …, 2022 - journals.lww.com
Summary Kir4. 2/Kir5. 1 activity in the proximal tubule plays a key role in regulating Na+, K+
and bicarbonate-transport through regulating electrogenic-Na+-bicarbonate-cotransporter …

Activation of Kir4. 1/Kir5. 1 contributes to the cyclosporin A‐induced stimulation of the renal NaCl cotransporter and hyperkalemic hypertension

ZX Gao, R Zhou, MY Li, ST Li, ZH Mao… - Acta …, 2023 - Wiley Online Library
Abstract Aim Cyclosporin A (CsA) is a widely used immunosuppressive drug that causes
hypertension and hyperkalemia. Moreover, CsA‐induced stimulation of the thiazide …

[HTML][HTML] Calcineurin inhibitors stimulate Kir4. 1/Kir5. 1 of the distal convoluted tubule to increase NaCl cotransporter

DD Zhang, XP Duan, K Mutig, F Rausch, Y Xiao… - JCI insight, 2023 - ncbi.nlm.nih.gov
We examine whether calcineurin or protein phosphatase 2B (PP2B) regulates the
basolateral inwardly rectifying potassium channel Kir4. 1/Kir5. 1 in the distal convoluted …

L-WNK1 is required for BK channel activation in intercalated cells

EC Ray, R Carrisoza-Gaytan… - American Journal …, 2021 - journals.physiology.org
Large-conductance K+ (BK) channels expressed in intercalated cells (ICs) in the
aldosterone-sensitive distal nephron (ASDN) mediate flow-induced K+ secretion. In the …

Crosstalk between epithelial sodium channels (ENaC) and basolateral potassium channels (Kir4.1/Kir5.1) in the cortical collecting duct

E Isaeva, R Bohovyk, M Fedoriuk… - British journal of …, 2022 - Wiley Online Library
Background and Purpose Inwardly rectifying K+ (Kir) channels located on the basolateral
membrane of epithelial cells of the distal nephron play a crucial role in K+ handling and BP …

KCNJ16-depleted kidney organoids recapitulate tubulopathy and lipid recovery upon statins treatment

E Sendino Garví, GJJ van Slobbe, EA Zaal… - Stem Cell Research & …, 2024 - Springer
Background The KCNJ16 gene has been associated with a novel kidney tubulopathy
phenotype, viz. disturbed acid–base homeostasis, hypokalemia and altered renal salt …

Angiotensin-ii-type-1a receptor (at1ar) and renal k+ wasting during overnight low-na+ intake

XP Duan, JY Zheng, Y Xiao, CB Zhang… - Journal of the …, 2024 - journals.lww.com
Background: Chronic Angiotensin-II (Ang-II) perfusion stimulates Kir4. 1/Kir5. 1 of the DCT
via angiotensin-II-type-1a-receptor (AT1aR) and low-sodium-intake also stimulates Kir4 …

ROMK channels are inhibited in the aldosterone-sensitive distal nephron of renal tubule Nedd4-2-deficient mice

DD Zhang, JY Zheng, XP Duan… - American Journal of …, 2022 - journals.physiology.org
We used whole cell recording to examine the renal outer medullary K+ channel (ROMK or
Kir1. 1) and epithelial Na+ channel (ENaC) in the late distal convoluted tubule (DCT2)/initial …

Kir5. 1 regulates Kir4. 2 expression and is a key component of the 50 pS inwardly-rectifying potassium channel in basolateral membrane of mouse proximal tubules

CB Zhang, Z Ding, XP Duan… - American Journal …, 2025 - journals.physiology.org
Kir5. 1 encoded by Kcnj16 is an inwardly-rectifying K+ channel-subunit and it possibly
interacts with Kir4. 2-subunit encoded by Kcnj15 for assembling a Kir4. 2/Kir5. 1 …