DH Lin, XP Duan, JY Zheng… - Current opinion in …, 2022 - journals.lww.com
Summary Kir4. 2/Kir5. 1 activity in the proximal tubule plays a key role in regulating Na+, K+ and bicarbonate-transport through regulating electrogenic-Na+-bicarbonate-cotransporter …
ZX Gao, R Zhou, MY Li, ST Li, ZH Mao… - Acta …, 2023 - Wiley Online Library
Abstract Aim Cyclosporin A (CsA) is a widely used immunosuppressive drug that causes hypertension and hyperkalemia. Moreover, CsA‐induced stimulation of the thiazide …
DD Zhang, XP Duan, K Mutig, F Rausch, Y Xiao… - JCI insight, 2023 - ncbi.nlm.nih.gov
We examine whether calcineurin or protein phosphatase 2B (PP2B) regulates the basolateral inwardly rectifying potassium channel Kir4. 1/Kir5. 1 in the distal convoluted …
EC Ray, R Carrisoza-Gaytan… - American Journal …, 2021 - journals.physiology.org
Large-conductance K+ (BK) channels expressed in intercalated cells (ICs) in the aldosterone-sensitive distal nephron (ASDN) mediate flow-induced K+ secretion. In the …
Background and Purpose Inwardly rectifying K+ (Kir) channels located on the basolateral membrane of epithelial cells of the distal nephron play a crucial role in K+ handling and BP …
E Sendino Garví, GJJ van Slobbe, EA Zaal… - Stem Cell Research & …, 2024 - Springer
Background The KCNJ16 gene has been associated with a novel kidney tubulopathy phenotype, viz. disturbed acid–base homeostasis, hypokalemia and altered renal salt …
XP Duan, JY Zheng, Y Xiao, CB Zhang… - Journal of the …, 2024 - journals.lww.com
Background: Chronic Angiotensin-II (Ang-II) perfusion stimulates Kir4. 1/Kir5. 1 of the DCT via angiotensin-II-type-1a-receptor (AT1aR) and low-sodium-intake also stimulates Kir4 …
DD Zhang, JY Zheng, XP Duan… - American Journal of …, 2022 - journals.physiology.org
We used whole cell recording to examine the renal outer medullary K+ channel (ROMK or Kir1. 1) and epithelial Na+ channel (ENaC) in the late distal convoluted tubule (DCT2)/initial …
CB Zhang, Z Ding, XP Duan… - American Journal …, 2025 - journals.physiology.org
Kir5. 1 encoded by Kcnj16 is an inwardly-rectifying K+ channel-subunit and it possibly interacts with Kir4. 2-subunit encoded by Kcnj15 for assembling a Kir4. 2/Kir5. 1 …